As such, there is tremendous interest within the clinical. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of carbohydrates, especially glucose from the blood into liver, fat and skeletal muscle cells. A trial comparing the efficacy and safety of insulin. It has a duration of action that lasts up to 42 hours compared to 18 to 26 hours provided by other marketed longacting. Jochum2 1 diabetes division, sanofi aventis, frankfurt, main, germany. Change the injection site regularly so that lumpiness under the skin does not develop. Insulin glargine is a recombinant human insulin analogue that does provide 24hour duration of action in most, but not all, patients with t1dm. Insulin glargine preparations from different manufacturers are. Newer agents for blood glucose control in type 2 diabetes. Insulin is one of many hormones that help the body turn the food we eat into energy. Insulin and its metabolic effects this information was ground breaking and way before its time, and to this day this information is still new to the vast majority of doctors in 2011. Dose adjustments and close metabolic monitoring is recommended if switching between insulin glargine preparations.
The subset of patients using insulin glargine alone n447 had a higher incidence of all cancers than those using other insulins only n32295 hr 1. Lantus insulin glargine 100 unitsml is the most prescribed long acting insulin. Carton of five 3 ml singlepatientuse solostar pens ndc 0088221905. Insulin glargine, a longacting form of insulin, works by replacing the insulin that is normally produced by the body and by helping the body to use sugar for energy. Development of a chemiluminescent assay for insulin glargine insulin glargine lantus is a insulin glargine lantus is a longacting insulin analogue, differing from human insulin by the substitution of asparagine for glycine at the cterminal end of the a chain and the addition of two arginine molecules to the cterminus of the b chain. Dm tipe 1 dm tipe 1 disebut juga iddm insulin dependent diabetes mellitus tjay dan rahardja, 2007. The two longacting insulin analogues artificial insulins, insulin detemir or insulin glargine differ in their mechanism of attaining protracted. Atkinson, in williams textbook of endocrinology thirteenth edition, 2016. Its available as the brandname drugs lantus, basaglar. Insulin degludec innusan is an ultralongacting basal insulin analogue that was developed by novo nordisk under the brand name tresiba. Lantus insulin glargine injection rdna origin is a recombinant human insulin analog indicated for oncedaily subcutaneous administration in the treatment of patients over 17 years of age with type 1 or type 2 diabetes mellitus who require basal longacting insulin for the. These authors to concluded that insulin glargine use was not associated with an increased risk of all cancers or sitespecific cancers in scotland over a 4 year.
It differs from human insulin in that the amino acid asparagine at position a21 is replaced by glycine, and two arginines are added to. Insulin glargine is an analog of human insulin with cterminal elongation of the beta chain by two arginine residues and replacement of asparagine in position a21 by glycine. It is the first longacting analog of human insulin to be approved for clinical use. Prescription lantus is a longacting insulin used to treat. How to use the lantus solostar pen insulin glargine. Diabetes tipe ini merupakan diabetes yang jarang atau sedikit populasinya, diperkirakan kurang dari 510. Insulin glargine is a longacting insulin used to treat diabetes. Insulin glargine is a longacting type of insulin that works slowly, over about 24 hours. Insulin is the most effective means of lowering blood glucose, allowing the body to maintain glucose within a normal range. Lantus insulin glargine rdna origin injection side. Insulin glargine is a longacting human insulin analog prepared using recombinant dna technology. Insulin glargine lantus, toujeo, mampu mencapai pembuluh darah dalam 11,5 jam dan mempertahankan kadar gula darah selama kurang lebih 20 jam. Dosis selanjutnya diatur menurut kebutuhan pasien,dengan dosis total harian berkisar dari 2100 iu.
Pasien tipe 2 yang telah diobati dengan obat hiperglikemia oral, memulai dengan insulin glargine dengan dosis 10 iu sekali sehari. Lowers blood glucose levels when rapidacting insulins stop working. The bioassay kits contain all the reagents needed for a complete assay including cells, detection reagents, cell plating reagent, positive control agonist, dilution buffer, and assay plates. Jenis dan kerja insulin sahabatdmsahabat diabetes muda. Insulin glargine lantus insulin glargine injection. Sistematis kerjanya yakni berinteraksi dengan membran pada sel luar sitoplasma dengan reseptor khusus guna membentuk kompleks reseptor insulin hingga merangsang proses intraseluler. Insulin glargine is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin glargine is used to improve blood sugar control in people with diabetes sulin glargine is for use in adults with type 1 or type 2 diabetes, and in children at least 6 years old with type 1 diabetes some brands of this medicine are for use. Insulin glargine is a prescription medication used to treat type 1 and type 2 diabetes. Insulin glargine is used to treat type 1 or type 2 diabetes in adults, and type 1 diabetes children who are at. Quantitation of insulin glargine in human plasma with a. Insulin glargine cannot be mixed with any other insulin b y virtue of its acidic ph and high zn content i.
Lantus solostar 100 unidadesml solucion inyectable en pluma precargada. Pro and juniorstar or the user manual for lantus solostar for. Insulin detemir versus insulin glargine for type 2 diabetes mellitus. Product monograph lantus insulin glargine injection. A disposable pen needle is attached to the end of the pen prior to injecting.
Transfer to a vial 35l of the sample solution from the assay. Setelah injeksi, insulin glargine dilepaskan secara perlahan dan terusmenerus ke dalam aliran darah. Biasanya, insulin longacting akan dikombinasikan dengan insulin jenis rapidacting atau shortacting. Basal insulin glargine 100 uml and prandial insulin lispro have been available for many years and there is a substantial evidence base to.
The abdomen belly is usually the best place to inject. Insulin glargine comes as a solution liquid to inject subcutaneously under the skin. Development of a chemiluminescent assay for insulin glargine. Lantus adalah nama merek dagang dari insulin glargine.
Tris buffer solution and 100l of enzyme solution, and incubate at 45 for 23 h. Provides a summary of interactions with vitamins, herbs, and food. Untuk pasien dengan resistensi insulin parah yang membutuhkan lebih dari 200 unit per hari, insulin dengan. It is administered via subcutaneous injection once daily to help control the blood sugar level of those with diabetes. Insulin glargine, marketed under the names lantus among others, is a long acting insulin, used. Mengenal jenisjenis insulin terbaru untuk pengobatan. Krishna wardhana sucipto sub bagian endokrinologi, metabolik dan diabetes bagian ilmu penyakit dalam fakultas kedokteran unsyiahbpk rsuza banda aceh pendahuluan. Donotmixinsulinglarginewithanyotherinsulinorsolution,orusesyringescontaining any other medicinal product or residue.
Millions of people every day count on lantus to help them manage their a1c and control their blood sugar. Insulin glargine, a recombinant protein, is a longacting insulin analogue given daily to diabetes patients to help control blood sugar level. Insulin glargine tidak diberikan secara intra vena karena dapat menyebabkan hipoglikemia. The initial total daily insulin requirement in insulin naive patients is generally 0.
Quench the digestion by adding 2l of phosphoric acid. Dibutuhkan sekitar 90 menit untuk mulai bekerja setelah injeksi, dan berhenti bekerja setelah sekitar 24 jam. Diabetes mellitus dm adalah suatu sindrom yang ditandai dengan hiperglikemia kronis dan gangguan metabolisme karbohidrat, protein. Insulin glargine should be injected into the fatty tissue under the skin subcutaneously. Australian public assessment for insulin glargine rbe. Insulin glargine, marketed under the names lantus among others, is a longacting insulin, used in the management of type i and type ii diabetes.
However, safety issues have been raised with these alternatives, as the alteration of the threedimensional structure may alter the interaction with the insulin andor igfi receptors and therefore lead to. Solution should be clear and colorlesswithnoparticulatematter. It is used once a day as an injection just under the skin. Insulin glargine side effects, uses, dosage, overdose. Marketed as lantus, insulin glargine has been one of the bestselling pharmaceutical products for the past five years. In recent years, recombinant dna technology has been used to design insulin molecules that overcome the limitations of regular insulin in mealtime supplementation. When you have diabetes mellitus, your body cannot make enough insulin or does not use. Lantusinsulin glargine injection rdna origin is a recombinant. Insulin glargine should not be diluted or mixed with any other insulin or solution. Insulin glargine adalah insulin yang berkerja jangka panjang.
Insulin glargine adalah longacting basal insulin analouge yang pertama kali dipergunakan dalam pengobatan dm baik tipe1 maupun tipe2, disuntikkan subkutan malam hari menjelang tidur. Toujeo insulin glargine rdna origin, suatu insulin basal kerja panjang yang digunakan sehari sekali, mengandung 300 unitml u300. Insulin glargine drug bnf content published by nice. Insulin glargine memiliki kelarutan dalam air yang rendah pada ph netral sedangkan pada ph 4 insulin glargine benarbenar larut. Millions of people every day count on lantus to help them manage their a1c. This analog is soluble in the acidic solution in which it is packaged but relatively insoluble in the physiologic ph of the extracellular fluid.
Secara kimia, insulin glargine adalah 21 agly30 b alarg30 b blinsulin manusia. Insulin analogues glargine detemir lantus with type 2 diabetes. Insulin glargine lantus insulin glargine injection 100 unitsml. Premixed preparations are a vailable with protamine insulin. You should use insulin glargine at the same time every day. This is done by using the glucose in the blood as quick energy. Risk of hypoglycaemia with insulin degludec versus insulin glargine u300 in insulintreated patients with type 2 diabetes. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Insulin from latin insula, island is a peptide hormone produced by beta cells of the pancreatic islets. Obat novorapid adalah golongan obat sekreagogue insulin yang dapat menekan tingkat gula darah berlebihan di dalam tubuh.
Carton of one 10 ml multipledose vial ndc 0088222033. Lantus insulin glargine dose, indications, adverse. Insulin glargine in type 1 diabetes mellitus full text. Lantus insulin glargine injection rdna origin is a recombinant human insulin analog indicated for oncedaily subcutaneous administration in the treatment of patients over 17 years of age with type 1 or type 2 diabetes mellitus who require basal longacting insulin for the control of hyperglycemia. Glargine lantus detemir levemir basal insulin is best starting insulin choice for most patients if fasting glucose above goal. Rosedale was one of the first to speak throughout the world detailing the critical importance of insulin to health and disease. It is not typically the recommended long acting insulin in the united kingdom. When you have diabetes mellitus, your body cannot make enough insulin or does. Also, insulin helps us store energy that we can use later. In people with diabetes, there is either a complete absence of this naturally occurring hormone type 1 diabetes or there is an issue with diminished insulin secretion andor insulin resistance type 2 diabetes. Insulin glargine is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Insulin glargine is used to improve blood sugar control in people with diabetes mellitus. Insulin glargine is a selfinjectable solution used to control high blood sugar hyperglycemia in people with type 1 and type 2 diabetes. Biological medicines must be prescribed and dispensed by brand name, see biological medicines and biosimilar medicines, under guidance on prescribing.
1349 725 223 73 1002 168 473 1556 1120 148 863 868 980 1057 1138 353 1283 1442 888 913 1425 913 1116 1460 610 1119 1275 521 283 946 692 1231 338 301 584 1149